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Controlling release kinetics of gentamicin from silica nano-carriers

Perni, Stefano, Martini-Gilching, Kerstin and Prokopovich, Polina 2018. Controlling release kinetics of gentamicin from silica nano-carriers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 541 , pp. 212-221. 10.1016/j.colsurfa.2017.04.063

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Abstract

Antibiotic release from a carrier can be employed to reduce the frequency of administration or prolong efficacy. In this work, we prepared silica nanoparticles loaded with gentamicin through different synthetis routes (entrapment, adsorption, covalent bonding and Layer-by-Layer (LbL)). The nanocarriers physical-chemical properties were characterised and antibiotic release from the nanocarriers was monitored. The nanoparticles prepared entrapping gentamicin gave the highest drug load but completed the release over a period of 4 h. No significant differences in antibiotic load were noticed between absorption or binding of gentamicin onto the silica nanoparticles surface; moreover the release of the drug occurred over 2 days in both cases. The nanoparticles coated with gentamicin through LbL technique released the antibiotic for 3 weeks. This work demonstrates that silica nanoparticles can be employed as antibiotic carriers providing a continuous release of antibiotic over a period that can be tuned through the choice of preparation method

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: Silica nanoparticles; Gentamicin; LbL; Antibiotic release
Publisher: Elsevier
ISSN: 0927-7757
Date of First Compliant Deposit: 2 May 2017
Date of Acceptance: 24 April 2017
Last Modified: 26 Jul 2018 10:14
URI: http://orca.cf.ac.uk/id/eprint/100225

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