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Heat-induced editing of HPV genes to clear mucocutaneous warts?

Piguet, Vincent 2017. Heat-induced editing of HPV genes to clear mucocutaneous warts? Journal of Investigative Dermatology 137 (4) , pp. 796-797. 10.1016/j.jid.2017.01.015

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Abstract

Hyperthermia increases expression of the antiviral cellular factors APOBEC3A and APOBEC3G and induces G-to-A or C-to-T mutations in human papilloma virus cervical cell lines and genital warts. This unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological mechanisms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 0022-202X
Last Modified: 15 Jul 2019 10:16
URI: http://orca.cf.ac.uk/id/eprint/100317

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