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A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells

Ahmed, Nisar, Shirinfar, Bahareh, Miriyala, Vijay Madhav, Choi, Seong-Kyoon, Lee, Kyeong-Min, Jeon, Won Bae, Park, Yu Shin and Nam, Hong Gil 2015. A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells. Supramolecular Chemistry 27 (7-8) , pp. 478-483. 10.1080/10610278.2014.989851

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Abstract

Fluorescent imaging probes have revolutionised cell biology by monitoring cellular objects. However, the lack of fluorescent probes with high selectivity for RNA has been a drawback. Thus, selective RNA binding for fluorescent sensors is essential. Here, we report the selective fluorescence enhancement upon addition of RNA. By exploiting a selective recognition of small tetra-cationic probe 1 for RNA, we also explain the possible binding mode for RNA. As a membrane-permeant fluorescence probe, 1 provides selective imaging of RNA not only in human neuroblastoma tumour SH-SY5Y cell line used for Parkinson's disease but also in the unicellular green alga cells. Further exploitation could open new opportunities in neurotoxin and cancer biology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: RNA recognition; Host–guest chemistry; Cationic probe; Confocal microscopy
Publisher: Taylor & Francis
ISSN: 1061-0278
Date of Acceptance: 17 November 2014
Last Modified: 04 Jun 2017 09:49
URI: http://orca.cf.ac.uk/id/eprint/100419

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