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Complete sequence of the FII plasmid p42-2, carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli

Yang, Qiu E., Walsh, Timothy Rutland, Liu, Bao Tao, Zou, Meng Ting, Deng, Hui, Fang, Liang Xing, Liao, Xiao Ping, Sun, Jian and Liu, Ya Hong 2016. Complete sequence of the FII plasmid p42-2, carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli. Antimicrobial Agents and Chemotherapy 60 (7) , pp. 4336-4338. 10.1128/AAC.00475-16

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Abstract

We sequenced a novel conjugative multidrug resistance IncF plasmid, p42-2, isolated from Escherichia coli strain 42-2, previously identified in China. p42-2 is 106,886 bp long, composed of a typical IncFII-type backbone (∼54 kb) and one distinct acquired DNA region spanning ∼53 kb, harboring 12 antibiotic resistance genes [blaCTX-M-55, oqxA, oqxB, fosA3, floR, tetA(A), tetA(R), strA, strB, sul2, aph(3′)-II, and ΔblaTEM-1]. The spread of these multidrug resistance determinants on the same plasmid is of great concern and, because of coresistance to antibiotics from different classes, is therapeutically challenging.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Society for Microbiology
ISSN: 0066-4804
Date of First Compliant Deposit: 21 September 2017
Date of Acceptance: 31 March 2016
Last Modified: 10 Oct 2017 14:40
URI: http://orca.cf.ac.uk/id/eprint/100804

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