Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders

Peall, Kathryn J., Lorentzos, M.S., Heyman, I., Tijssen, M.A.J., Owen, Michael J., Dale, R.C. and Kurian, M.A. 2017. A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders. Neuroscience & Biobehavioral Reviews 80 , pp. 23-35. 10.1016/j.neubiorev.2017.05.014

[img]
Preview
PDF - Accepted Post-Print Version
Download (524kB) | Preview

Abstract

Psychiatric symptoms are an increasingly recognised feature of movement disorders. Recent identification of causative genes and autoantibodies has allowed detailed analysis of aetiologically homogenous subgroups, thereby enabling determination of the spectrum of psychiatric symptoms in these disorders. This review evaluates the incidence and type of psychiatric symptoms encountered in patients with movement disorders. A broad spectrum of psychiatric symptoms was identified across all subtypes of movement disorder, with depression, generalised anxiety disorder and obsessive-compulsive disorder being most common. Psychosis, schizophrenia and attention deficit hyperactivity disorder were also identified, with the psychiatric symptoms often predating onset of the motor disorder. The high incidence of psychiatric symptoms across such a wide range of movement disorders suggests a degree of common or overlapping pathogenic mechanisms. Our review demonstrates the need for increased clinical awareness of such co-morbidities, which should facilitate early neuropsychiatric intervention and allied specialist treatment for patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Outline Highlights Abstract Keywords 1. Introduction 2. Methods 3. Parkinsonism 4. Heredo-degenerative disorders 5. Genetic dystonia 6. Genetic chorea 7. Immune-mediated movement disorders 8. Discussion 9. Conclusion Acknowledgements Appendix A. Supplementary data References Show full outline Figures (3) Fig. 1. Proposed main mechanisms and hypothesised neural pathways involved in movement… Fig. 2. A proposed but hypothetical schematic model of neurotransmission and sites of… Fig. 3. Schematic representation of psychiatric symptoms reported in movement disorder… Tables (4) Table 1 Table 2 Table 3 Table 4 Extras (6) Document Document Document Document Document Supplementary Fig. S1 Elsevier Neuroscience & Biobehavioral Reviews Volume 80, September 2017, Pages 23-35 Neuroscience & Biobehavioral Reviews Review article A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders . Author links open the author workspace.K.J.Pealla. Numbers and letters correspond to the affiliation list. Click to expose these in author workspaceOpens the author workspace1. Numbers and letters correspond to the affiliation list. Click to expose these in author workspaceOpens the author workspace. Author links open the author workspace.M.S.Lorentzosb. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace1. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace. Author links open the author workspace.I.Heymanc. Numbers and letters correspond to the affiliation list. Click to expose these in author workspaced. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace. Author links open the author workspace.M.A.J.Tijssene. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace. Author links open the author workspace.M.J.Owena. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace. Author links open the author workspace.R.C.Daleb. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace2. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace. Author links open the author workspace.M.A.Kuriand. Numbers and letters correspond to the affiliation list. Click to expose these in author workspacef. Numbers and letters correspond to the affiliation list. Click to expose these in author workspaceOpens the author workspace2. Numbers and letters correspond to the affiliation list. Click to expose these in author workspaceOpens the author workspace a MRC Centre for Neuropsychiatric Genetics and Genomics, Hadyn Ellis Building, Heath Park, Cardiff, CF24 4HQ, UK b Movement Disorders Clinic, The Children's Hospital at Westmead, University of Sydney, Sydney, NSW, Australia c Department of Psychological Medicine, Great Ormond Street Hospital, London, UK d Developmental Neurosciences Programme, UCL-Institute of Child Health, London, UK e Department of Neurology, University of Groningen, Groningen, The Netherlands f Department of Neurology, Great Ormond Street Hospital, London, UK Received 21 March 2017, Revised 10 May 2017, Accepted 12 May 2017, Available online 18 May 2017. crossmark-logo Show less https://doi.org/10.1016/j.neubiorev.2017.05.014Get rights and content Highlights • Psychiatric disorders form part of the disorder phenotype in many movement disorders. • Most commonly identified disorders: anxiety, depressive disorders and psychosis. • Psychiatric symptoms frequently pre-date onset of the motor disorder. • Nature of psychiatric symptoms frequently differ between distinct movement disorders. Abstract Psychiatric symptoms are an increasingly recognised feature of movement disorders. Recent identification of causative genes and autoantibodies has allowed detailed analysis of aetiologically homogenous subgroups, thereby enabling determination of the spectrum of psychiatric symptoms in these disorders. This review evaluates the incidence and type of psychiatric symptoms encountered in patients with movement disorders. A broad spectrum of psychiatric symptoms was identified across all subtypes of movement disorder, with depression, generalised anxiety disorder and obsessive-compulsive disorder being most common. Psychosis, schizophrenia and attention deficit hyperactivity disorder were also identified, with the psychiatric symptoms often predating onset of the motor disorder. The high incidence of psychiatric symptoms across such a wide range of movement disorders suggests a degree of common or overlapping pathogenic mechanisms. Our review demonstrates the need for increased clinical awareness of such co-morbidities, which should facilitate early neuropsychiatric intervention and allied specialist treatment for patients. Keywords Movement disorders Genetics Immune mediated Psychiatric phenotype
Additional Information: This journal has an embargo period of 18 months https://www.elsevier.com/journals/neuroscience-and-biobehavioral-reviews/0149-7634/open-access-options
Publisher: Elsevier
ISSN: 0149-7634
Date of First Compliant Deposit: 25 May 2017
Date of Acceptance: 12 May 2017
Last Modified: 27 Nov 2018 20:30
URI: http://orca.cf.ac.uk/id/eprint/100876

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics