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Cutting edge: a dual TLR2 and TLR7 ligand induces highly potent humoral and cell-mediated immune responses

Gutjahr, Alice, Papagno, Laura, Nicoli, Francesco, Lamoureux, Alain, Vernejoul, Fabienne, Lioux, Thierry, Gostick, Emma, Price, David, Tiraby, Gérard, Perouzel, Eric, Appay, Victor, Verrier, Bernard and Paul, Stéphane 2017. Cutting edge: a dual TLR2 and TLR7 ligand induces highly potent humoral and cell-mediated immune responses. Journal of Immunology 198 (11) , pp. 4205-4209. 10.4049/jimmunol.1602131

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Abstract

TLR agonists are currently being developed and tested as adjuvants in various formulations to optimize the immunogenicity and efficacy of vaccines. The aim of this study was to evaluate the immunostimulatory properties of a novel compound incorporating covalently linked moieties designed to stimulate both TLR2 and TLR7. This dual TLR2/TLR7 agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8+ T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced TH1/TH2 profile in mice. Collectively, these data reveal the potential utility of chimeric adjuvants with synergistic activities mediated via TLRs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Association of Immunologists
ISSN: 0022-1767
Date of First Compliant Deposit: 2 June 2017
Date of Acceptance: 28 March 2017
Last Modified: 19 Jun 2017 10:36
URI: http://orca.cf.ac.uk/id/eprint/101073

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