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The thyroid, the eyes and the gut: a possible connection

Covelli, D. and Ludgate, Marian Elizabeth 2017. The thyroid, the eyes and the gut: a possible connection. Journal of Endocrinological Investigation 40 (6) , pp. 567-576. 10.1007/s40618-016-0594-6

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Abstract

Graves’ disease (GD) is an autoimmune disorder responsible for 60–90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 population per year in England. Graves’ orbitopathy (GO) is the most frequent extrathyroidal manifestation, not provoked directly by abnormal thyroid hormone levels, but by the consequence of the underlying autoimmune process. The aetiology of autoimmune disorders is due to an interplay between susceptibility genes and environmental factors, such as infections and stress. What triggers the autoimmune reaction to a specific site of the body is not yet clearly understood. The lack of knowledge in GD and GO pathogenesis implicates therapies that only limit damage but do not prevent disease onset.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Springer
ISSN: 1720-8386
Funders: EU FP7
Date of First Compliant Deposit: 5 September 2017
Date of Acceptance: 5 December 2016
Last Modified: 10 Jan 2018 06:31
URI: http://orca.cf.ac.uk/id/eprint/101154

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