Escott-Price, Valentina, Myers, Amanda J, Huentelman, Matt and Hardy, John
2017.
Polygenic risk score analysis of pathologically confirmed Alzheimer's disease.
Annals of Neurology
82
(2)
, pp. 311-314.
10.1002/ana.24999
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Official URL: http://dx.doi.org/10.1002/ana.24999
Abstract
Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer’s disease have given Area Under the Curve estimates of <80%. However, these have been based on the genetic analysis of clinical case control series. Here we apply the same analytic approaches to a pathological case control series and show a predictive AUC of 84%. We suggest that this analysis has clinical utility and that there is limited room for further improvement using genetic data.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
Subjects: | R Medicine > R Medicine (General) |
Uncontrolled Keywords: | Alzheimer’s disease, genetics, pathology |
Publisher: | Wiley |
ISSN: | 0364-5134 |
Date of First Compliant Deposit: | 21 June 2017 |
Date of Acceptance: | 18 July 2017 |
Last Modified: | 20 Jan 2021 00:34 |
URI: | http://orca.cf.ac.uk/id/eprint/101628 |
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