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Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival

Zabkiewicz, Catherine, Resaul, Jeyna, Hargest, Rachel, Jiang, Wen and Ye, Lin 2017. Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival. Cancer Genomics Proteomics 14 (4) , pp. 241-251. 10.21873/cgp.20035

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Abstract

Background/Aim: Activin and its antagonist follistatin (FST) have been implicated in several solid tumours. This study investigated the role of FST in breast cancer. Materials and Methods: FST expression was examined using reverse transcription polymerase chain reaction (RT-PCR), real-time quantitative polymerase chain reaction (qPCR) and immunohistochemistry in a cohort of breast cancer samples. Expression was correlated to pathological and prognostic parameters in our patient cohort. FST was overexpressed in MCF-7 cells and assays for growth and invasion were performed. Results: FST is expressed in breast tissue, in the cytoplasm of mammary epithelial cells. Expression was decreased in breast cancer tissue in comparison to normal mammary tissue. Over-expression of FST in vitro led to significantly increased growth rate and reduced invasion. Higher FST associates with lower-grade tumours and better survival. Conclusion: Our results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: International Institute of Anticancer Research
ISSN: 1109-6535
Date of First Compliant Deposit: 29 June 2017
Date of Acceptance: 31 May 2017
Last Modified: 25 Jun 2019 22:05
URI: http://orca.cf.ac.uk/id/eprint/101923

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