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Antibiotics, gut microbiota, environment in early life and type 1 diabetes

Hu, Youjia, Wong, Florence Susan and Wen, Li 2017. Antibiotics, gut microbiota, environment in early life and type 1 diabetes. Pharmacological Research 119 , pp. 219-226. 10.1016/j.phrs.2017.01.034

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Abstract

The gut microbiota interact with innate immune cells and play an important role in shaping the immune system. Many factors may influence the composition of the microbiota such as mode of birth, diet, infections and medication including antibiotics. In diseases with a multifactorial etiology, like type 1 diabetes, manipulation and alterations of the microbiota in animal models have been shown to influence the incidence and onset of disease. The microbiota are an important part of the internal environment and understanding how these bacteria interact with the innate immune cells to generate immune tolerance may open up opportunities for development of new therapeutic strategies. In this review, we discuss recent findings in relation to the microbiota, particularly in the context of type 1 diabetes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1043-6618
Date of First Compliant Deposit: 14 July 2017
Date of Acceptance: 6 January 2017
Last Modified: 14 Jul 2017 10:31
URI: http://orca.cf.ac.uk/id/eprint/102035

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