Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study

Taylor, Peter, Sayers, Adrian, Okosieme, Onyebuchi, Das, Gautam, Draman, Mohd S., Tabasum, Arshiya, Abusahmin, Hussam, Rahman, Mohammad, Stevenson, Kirsty, Groom, Alix, Northstone, Kate, Woltersdorf, Wolf, Taylor, Andrew, Ring, Susan, Lazarus, John H., Gregory, John W., Rees, Dafydd, Timpson, Nicholas and Dayan, Colin 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology & Metabolism 102 (7) , pp. 2508-2515. 10.1210/jc.2016-3605

[img]
Preview
PDF - Published Version
Download (327kB) | Preview

Abstract

Context: Serum thyroid hormone levels differ between children and adults, but have not been studied longitudinally through childhood. Objective: To assess changes in thyroid-stimulating hormone (TSH) and thyroid hormone levels over childhood and their interrelationships. Design: Cohort study. Setting: The Avon Longitudinal Study of Parents and Children, a population-based birth cohort. Participants: A total of 4442 children who had thyroid function measured at age 7, and 1263 children who had thyroid function measured at age 15. Eight hundred eighty-four children had measurements at both ages. Main Outcome Measures: Reference ranges for TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), their longitudinal stability, and interrelationships. Results: Children at age 7 years had a higher FT3 [6.17 pmol/L, standard deviation (SD) 0.62] than children at age 15 (5.83 pmol/L, SD 0.74); P , 0.0001 with 23.2% of children at age 7 having FT3 above the adult reference range. Higher FT3 levels at age 7 in boys (P = 0.0001) and girls (P = 0.04) were associated with attainment of a more advanced pubertal stage at age 13. TSH was positively associated with FT3 at age 7 and age 15 even after adjusting for confounders. In contrast, TSH was negatively associated with FT4

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: The Endocrine Society
ISSN: 0021-972X
Date of First Compliant Deposit: 10 July 2017
Date of Acceptance: 24 April 2017
Last Modified: 07 Dec 2017 15:48
URI: http://orca.cf.ac.uk/id/eprint/102229

Citation Data

Cited 2 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics