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A biased view toward celiac disease

Rossjohn, Jamie and Koning, F. 2016. A biased view toward celiac disease. Mucosal Immunology 9 (3) , pp. 583-586. 10.1038/mi.2016.17

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Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1933-0219
Date of First Compliant Deposit: 10 July 2017
Date of Acceptance: 23 February 2016
Last Modified: 19 Jun 2019 10:32

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