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Tris(2,4,6-trifluorophenyl)borane: an efficient hydroboration catalyst

Lawson, James, Wilkins, Lewis and Melen, Rebecca 2017. Tris(2,4,6-trifluorophenyl)borane: an efficient hydroboration catalyst. Chemistry - a European Journal 23 (46) , pp. 10997-11000. 10.1002/chem.201703109

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Abstract

The metal-free catalyst tris(2,4,6-trifluorophenyl)borane has demonstrated its extensive applications in the 1,2-hydroboration of numerous unsaturated reagents, namely alkynes, aldehydes and imines, consisting of a wide array of electron-withdrawing and donating functionalities. A range of over 50 borylated products are reported, with many reactions proceeding with low catalyst loading under ambient conditions. These pinacol boronate esters, in the case of aldehydes and imines, can be readily hydrolyzed to leave the respective alcohol and amine, whereas alkynyl substrates result in vinyl boranes. This is of great synthetic use to the organic chemist.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: WileyBlackwell
ISSN: 0947-6539
Funders: EPSRC
Date of First Compliant Deposit: 18 July 2017
Date of Acceptance: 6 July 2017
Last Modified: 28 Oct 2018 21:58
URI: http://orca.cf.ac.uk/id/eprint/102560

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