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Analysis of fascin-1 in relation to gleason risk classification and nuclear ets-related gene status of human prostate carcinomas: an immunohistochemical study of clinically annotated tumours from the Wales Cancer Bank

Jefferies, Matthew T., Pope, Christopher, Kynaston, Howard, Clarke, Alan R., Martin, Richard and Adams, Josephine 2017. Analysis of fascin-1 in relation to gleason risk classification and nuclear ets-related gene status of human prostate carcinomas: an immunohistochemical study of clinically annotated tumours from the Wales Cancer Bank. Biomarkers in Cancer 9 , pp. 1-8. 10.1177/1179299X17710944

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Abstract

Although prostate-specific antigen (PSA) testing can identify early-stage prostate cancers, additional biomarkers are needed for risk stratification. In one study, high levels of the actin-bundling protein, fascin-1, were correlated with lethal-phase, hormone-refractory prostate cancer. Analyses of independent samples are needed to establish the value of fascin-1 as a possible biomarker. We examined fascin-1 by immunohistochemistry in tumour specimens from the Wales Cancer Bank in comparison with nuclear-located ETS-related gene (ERG), an emerging marker for aggressive prostate cancer. Fascin-1 was elevated in focal areas of a minority of tumours, yet fascin-1-positivity did not differentiate tumours of low-, intermediate-, or high-risk Gleason scores and did not correlate with PSA status or biochemical relapse after surgery. Stromal fascin-1 correlated with high Gleason score. Nuclear ERG was upregulated in tumours but not in stroma. The complexities of fascin-1 status indicate that fascin-1 is unlikely to provide a suitable biomarker for prediction of aggressive prostate cancers

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: Fascin, ERG, prostate cancer, tumour progression, PSA, Gleason
Publisher: Sage
ISSN: 1179-299X
Date of First Compliant Deposit: 25 July 2017
Date of Acceptance: 21 April 2017
Last Modified: 22 Jan 2018 14:52
URI: http://orca.cf.ac.uk/id/eprint/102588

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