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Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex

Mercurio, Sara, Latinkic, Branko, Itasaki, Nobue, Krumlauf, Robb and Smith, J. C. 2004. Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 131 (9) , pp. 2137-2147. 10.1242/dev.01045

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Abstract

Connective-tissue growth factor (CTGF) is a member of the CCN family of secreted proteins. CCN family members contain four characteristic domains and exhibit multiple activities: they associate with the extracellular matrix, they can mediate cell adhesion, cell migration and chemotaxis, and they can modulate the activities of peptide growth factors. Many of the effects of CTGF are thought to be mediated by binding to integrins, whereas others may be because of its recently identified ability to interact with BMP4 and TGF?. We demonstrate, using Xenopus embryos, that CTGF also regulates signalling through the Wnt pathway, in accord with its ability to bind to the Wnt co-receptor LDL receptor-related protein 6 (LRP6). This interaction is likely to occur through the C-terminal (CT) domain of CTGF, which is distinct from the BMP- and TGF?-interacting domain. Our results define new activities of CTGF and add to the variety of routes through which cells regulate growth factor activity in development, disease and tissue homeostasis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
ISSN: 0950-1991
Last Modified: 04 Jun 2017 01:37
URI: http://orca.cf.ac.uk/id/eprint/1027

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