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Genetic prediction of myopia: Prospects and challenges

Guggenheim, Jeremy, Ghorbani Mojarrad, Neema, Williams, Cathy and Flitcroft, D. Ian 2017. Genetic prediction of myopia: Prospects and challenges. Ophthalmic and Physiological Optics 37 (5) , pp. 549-556. 10.1111/opo.12403

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Abstract

Appeals have been made for eye care professionals to start prescribing anti-myopia therapies as part of their routine management of myopic children.[1-3] These calls are fuelled by two key considerations. Firstly, that interventions to slow myopia progression have shown success in randomized controlled trials (RCTs)[4-7], and secondly, appreciation that the risk of sight-threatening complications rises dose-dependently with the level of myopia.[8, 9] Notwithstanding existing gaps in knowledge regarding the efficacy of current treatments (see below), these considerations argue that myopia control interventions should be widely adopted, and that they should be instigated at an early age – especially in children most at risk – in order to reduce the final level of myopia. Therefore in managing a child with myopia, an eye care professional would have to decide not only which therapy to recommend, but at what age to start treatment. In this review we discuss the future role of genetic prediction in helping clinicians treat myopia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Publisher: Wiley-Blackwell
ISSN: 0275-5408
Funders: College of Optometrists, NIHR
Date of First Compliant Deposit: 20 July 2017
Date of Acceptance: 7 July 2017
Last Modified: 27 Nov 2018 21:13
URI: http://orca.cf.ac.uk/id/eprint/102707

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