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Transcriptional profiling of sonic hedgehog in a prospective cohort of breast cancer in a Pakistani population

Kiran Riaz, Syeda, Ye, Lin, Sahar, Namood E., Aman, D., Qadir, J., Sarwar Khan, J., Saeed, M., Jiang, Wen Guo and Faraz Arshad Malik, M. 2017. Transcriptional profiling of sonic hedgehog in a prospective cohort of breast cancer in a Pakistani population. Anticancer Research 37 (8) , pp. 4449-4454. 10.21873/anticanres.11840

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Background/Aim: Constitutive activation of Sonic hedgehog (SHH) has been observed in different types of cancers. In the present study, expressional profiling of SHH in a breast cancer cohort (n=150) of a Pakistani population and its association with different molecular subtypes have been explored. Materials and Methods: qRT-PCR and IHC were performed for expression analysis of SHH and its association with ER, PR, HER2 and Ki-67 were also statistically analyzed. Results: A significant over-expression of SHH was observed in tumor tissues in comparison to their respective controls (p<0.0001). A strong positive correlation was seen between SHH and proliferation marker (r=0.635, p=0). SHH expression was significantly high among patients with advanced tumor grade, stage, nodal involvement and metastasis. Furthermore, both luminal-B and triple-negative subtypes of cohort showed increased expression of SHH. Conclusion: Based on these findings, SHH may be used as a potential biomarker for breast carcinogenesis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: International Institute of Anticancer Research
ISSN: 0250-7005
Funders: National Research Program for University of the Higher Education Commission of Pakistan and Cardiff University
Date of First Compliant Deposit: 11 August 2017
Date of Acceptance: 13 June 2017
Last Modified: 22 Jan 2018 12:17

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