Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

1.12 A˚ resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2

Coates, Katie, Walsh, Timothy R., Spencer, James and Hinchliffe, Philip 2017. 1.12 A˚ resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2. Acta Crystallographica Section F Structural Biology Communications 73 (8) , pp. 443-449. 10.1107/S2053230X17009669

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanol­amine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 å resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an accurate starting model for further mechanistic studies.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: International Union of Crystallography
ISSN: 2053-230X
Date of First Compliant Deposit: 14 August 2017
Date of Acceptance: 30 June 2017
Last Modified: 23 Aug 2017 04:32
URI: http://orca.cf.ac.uk/id/eprint/103558

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics