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The burden of common skin diseases assessed with the EQ5D: a European multicentre study in 13 countries

Balieva, F., Kupfer, J., Lien, L., Gieler, U., Finlay, Andrew Yule, Tomás-Aragonés, L., Poot, F., Misery, L., Sampogna, F., van Middendorp, H., Halvorsen, J.A., Szepietowski, J.C., Lvov, A., Marrón, S.E., Salek, M.S. and Dalgard, F.J. 2017. The burden of common skin diseases assessed with the EQ5D: a European multicentre study in 13 countries. British Journal of Dermatology 176 (5) , pp. 1170-1178. 10.1111/bjd.15280

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Background Generic instruments measuring health-related quality of life (HRQoL), like EQ5D™, enable comparison of skin diseases with healthy populations and nondermatological medical conditions, as well as calculation of utility data. Objectives To measure HRQoL in patients with common skin diseases and healthy controls across Europe using the EQ5D. Methods This multicentre observational cross-sectional study was conducted in 13 European countries. Each dermatology clinic recruited at least 250 consecutive adult outpatients to complete questionnaires, including the EQ5D. Results There were 5369 participants (4010 patients and 1359 controls). Mean ± SD self-rated health state reported by patients was 69·9 ± 19·7; for controls it was 82·2 ± 15·5. When adjusted for confounding factors, including comorbidity, mean patient EQ visual analogue scores were 10·5 points lower than for controls (standardized β = −0·23). Odds ratio with 95% confidence interval for impairment in all five dimensions of EQ5D adjusted for confounders was doubled for patients compared with controls. Patients with hidradenitis suppurativa (HS), blistering conditions, leg ulcers, psoriasis and eczemas had the highest risk for reduction in HRQoL in most dimensions (2–10-fold). Data on differences of impairment by dimensions offer new insights. Conclusions This study confirms the large impact skin conditions have on patients’ well-being, differentiating between aspects of HRQoL. Patients with HS, blistering diseases, leg ulcers, infections and most chronic skin diseases reported reduced HRQoL compared with patients with chronic obstructive lung disease, diabetes mellitus, cardiovascular disease and cancers. These findings are important in the prioritization of resource allocation between medical fields and within dermatological subspecialities.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Wiley-Blackwell
ISSN: 0007-0963
Funders: Southeastern Norway Regional Health Authority, Norwegian Medical Association, Stavanger University Hospital.
Date of Acceptance: 29 December 2016
Last Modified: 22 Jan 2019 14:59

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