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Can we use biomarkers of coagulation to predict which patients with foot and ankle injury will develop vein thrombosis?

Hickey, Benjamin, Cleves, Andrew, Alikhan, Raza, Nokes, Leonard and Perera, Anthony 2019. Can we use biomarkers of coagulation to predict which patients with foot and ankle injury will develop vein thrombosis? Foot and Ankle Surgery 25 (1) , pp. 59-62. 10.1016/j.fas.2017.08.002

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Abstract

Background Our aim was to determine whether plasma levels of Tissue Factor (TF), Vascular Cell Adhesion Molecule 1 (VCAM-1), Interleukin 6 (IL-6) or D-dimer after foot and ankle injury could predict which patients would develop deep vein thrombosis (DVT). Methods Patients aged 18–60 years with acute foot and ankle injury had venous blood sample to measure TF, VCAM-1, IL-6 and D-dimer within 3 days of injury. Patients had bilateral lower limb venous ultrasound to assess for DVT on discharge from clinic. Results 21 of 77 patients were found to have DVT (27%). There was no statistically significant association between levels of TF, VCAM-1, IL-6 or D-dimer and subsequent development of DVT. Conclusion Tissue Factor (TF), Vascular Cell Adhesion Molecule-1 (VCAM-1), Interleukin-6 (IL-6) and D-dimer levels were not associated with development deep vein thrombosis in patients with acute foot and ankle injury.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Publisher: Elsevier
ISSN: 1268-7731
Date of First Compliant Deposit: 22 August 2017
Date of Acceptance: 4 August 2017
Last Modified: 27 Apr 2019 00:56
URI: http://orca.cf.ac.uk/id/eprint/103832

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