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Trismus following different treatment modalities for head and neck cancer: a systematic review of subjective measures

Loh, Sook Yin, McLeod, Robert William J. and Elhassan, Hassan 2017. Trismus following different treatment modalities for head and neck cancer: a systematic review of subjective measures. European Archives of Oto-Rhino-Laryngology 274 (7) , pp. 2695-2707. 10.1007/s00405-017-4519-6

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The aim of this review was to compare systematically the subjective measure of trismus between different interventions to treat head and neck cancer, particularly those of the oropharynx. Using The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) Guidelines, Six databases were searched for the text using various terms which include "oropharyngeal/head and neck cancer", "trismus/mouth opening" and the various treatment modalities. Included in the review were clinical studies (> or =10 patients). Three observers independently assessed the papers identified. Among the six studies reviewed, five showed a significantly worst outcome with regard to the quality-of-life questionnaire scores for a radiotherapy or surgery and radiotherapy (RT) ± chemotherapy or chemoradiotherapy when compared to surgery alone. Only one study showed no significant difference between surgery alone and other treatment modalities. Subjective quality-of-life measures are a concurrent part of modern surgical practice. Although subjective measures were utilised to measure post operative trismus successfully, there was no consensus as to which treatment modality had overall better outcomes, with conflicting studies in keeping with the current debate in this field. Larger and higher quality studies are needed to compare all three treatment modalities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: Chemotherapy; Oropharyngeal carcinoma; Quality of life; Radiotherapy; Surgery; Trismus
Publisher: Springer
ISSN: 0937-4477
Date of First Compliant Deposit: 13 October 2017
Date of Acceptance: 21 February 2017
Last Modified: 07 Dec 2019 03:37

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