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Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome

Shorning, Boris and Clarke, Alan R. 2016. Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome. Seminars in Cell and Developmental Biology 52 , pp. 21-29. 10.1016/j.semcdb.2016.02.015

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Abstract

We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative and often carcinogenic pathways to maintain cellular energy levels. It therefore appears that although LKB1 deficiency can suppress oncogenic transformation in the short term, it can ultimately lead to more progressed and malignant phenotypes by driving abnormal cell differentiation, genomic instability and increased tumour heterogeneity.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Uncontrolled Keywords: Peutz–Jeghers syndrome, LKB1 kinase, Metabolism, Tumourigenesis
Publisher: Elsevier
ISSN: 1084-9521
Date of Acceptance: 8 February 2016
Last Modified: 25 Aug 2017 09:39
URI: http://orca.cf.ac.uk/id/eprint/103993

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