Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The molecular determinants of CD8 co-receptor function

Cole, David K., Laugel, Bruno, Clement, Mathew, Price, David A., Wooldridge, Linda and Sewell, Andrew K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Full text not available from this repository.

Abstract

CD8+ T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein ‘co-receives’ antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 0019-2805
Date of First Compliant Deposit: 18 September 2017
Date of Acceptance: 10 July 2012
Last Modified: 27 Jul 2019 22:04
URI: http://orca.cf.ac.uk/id/eprint/104742

Citation Data

Cited 25 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item