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Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes

Li, H., Ye, C., Ji, G., Wu, X., Xiang, Z., Li, Y., Cao, Y., Liu, X., Douek, D. C., Price, D. A. and Han, J. 2012. Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes. Journal of Immunology 189 (5) , pp. 2404-2413. 10.4049/jimmunol.1102087

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Abstract

Overlap of TCR repertoires among individuals provides the molecular basis for public T cell responses. By deep-sequencing the TCRβ repertoires of CD4+CD8+ thymocytes from three individual mice, we observed that a substantial degree of TCRβ overlap, comprising ∼10–15% of all unique amino acid sequences and ∼5–10% of all unique nucleotide sequences across any two individuals, is already present at this early stage of T cell development. The majority of TCRβ sharing between individual thymocyte repertoires could be attributed to the process of convergent recombination, with additional contributions likely arising from recombinatorial biases; the role of selection during intrathymic development was negligible. These results indicate that the process of TCR gene recombination is the major determinant of clonotype sharing between individuals.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Association of Immunologists
ISSN: 0022-1767
Date of First Compliant Deposit: 18 September 2017
Date of Acceptance: 23 June 2012
Last Modified: 21 Sep 2017 11:42
URI: http://orca.cf.ac.uk/id/eprint/104746

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