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Novel viral vectors in infectious diseases

Humphreys, Ian R. and Sebastian, Sarah 2018. Novel viral vectors in infectious diseases. Immunology 153 (1) , pp. 1-9. 10.1111/imm.12829

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Abstract

Since the development of vaccinia virus as a vaccine vector in 1984, the utility of numerous viruses in vaccination strategies has been explored. In recent years, key improvements to existing vectors such as those based on adenovirus have led to significant improvements in immunogenicity and efficacy. Furthermore, exciting new vectors that exploit viruses such as cytomegalovirus (CMV) and vesicular stomatitis virus (VSV) have emerged. Herein, we summarize these recent developments in viral vector technologies, focusing on novel vectors based on CMV, VSV, measles and modified adenovirus. We discuss the potential utility of these exciting approaches in eliciting protection against infectious diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley Blackwell
ISSN: 0019-2805
Funders: Wellcome Trust
Date of First Compliant Deposit: 28 September 2017
Date of Acceptance: 4 September 2017
Last Modified: 11 Mar 2019 10:06
URI: http://orca.cf.ac.uk/id/eprint/104956

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