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Adoptive transfer of autoimmune diabetes using immunodeficient Non Obese Diabetic (NOD) mice

De Leenheer, Evy and Wong, F. Susan 2016. Adoptive transfer of autoimmune diabetes using immunodeficient Non Obese Diabetic (NOD) mice. In: Gillespie, Kathleen M. ed. Type-1 Diabetes: Methods and Protocols, Vol. 1433. Methods in Molecular Biology, Humana Press, New York, NY, pp. 135-140. (10.1007/7651_2015_294)

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Abstract

Studying Type 1 Diabetes (T1D) in the non-obese diabetic (NOD) mouse model can be cumbersome as onset of disease does not usually occur naturally prior to the age of 12-14 weeks and is often restricted to female mice. Furthermore, the onset of disease occurs at random, which makes studying T1D in statistically meaningful cohorts of NOD mice a challenge. Transfer models of T1D into immunodeficient mice, such as NOD SCID mice, allows the study of potential therapeutic interventions in larger cohorts of animals, over shorter periods of time. In this chapter we discuss the adoptive transfer of diabetes into immunodeficient mice on the NOD genetic background that are generally available to the research community.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Humana Press, New York, NY
ISBN: 9781493936410
ISSN: 1064-3745
Funders: MRC
Date of First Compliant Deposit: 7 October 2017
Date of Acceptance: 14 August 2015
Last Modified: 09 Oct 2017 10:32
URI: http://orca.cf.ac.uk/id/eprint/105270

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