Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2008. IFN-α can both protect against and promote the development of Type 1 diabetes. Annals of the New York Academy of Sciences 1150 (1) , pp. 187-189. 10.1196/annals.1447.031 |
Abstract
Viral infection has been hypothesized to be one of the environmental triggers for the development of type 1 diabetes. Infection induces a large amount of interferon-α (IFN-α) produced by dendritic cells and other cells. To test the role of IFN-α in the development of diabetes, we have used three different experimental approaches in both diabetes- prone and -resistant animal models for type 1 diabetes. Our results suggested that a viral mimic or IFN-α can either suppress or promote the development of autoimmune diabetes, depending on the model system. It is likely that IFN-α plays a complex role in the etiology of type 1 diabetes.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Wiley-Blackwell |
ISSN: | 0077-8923 |
Last Modified: | 03 Nov 2022 09:33 |
URI: | https://orca.cardiff.ac.uk/id/eprint/105283 |
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