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The role of toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice

Wong, F. Susan, Hu, Changyun, Zhang, Li, Du, Wei, Alexopoulou, Lena, Flavell, Richard A. and Wen, Li 2008. The role of toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Annals of the New York Academy of Sciences 1150 (1) , pp. 146-148. 10.1196/annals.1447.039

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Abstract

Innate immunity is mediated, at least in part, through a number of receptors known as Toll-like receptors (TLRs), which are activated by different microbial stimuli. Adaptive immunity, including autoimmunity, follows the innate response in a more specific manner. To investigate the roles of TLR3 and TLR9 in the development of type 1 diabetes, we generated NOD mice that are deficient in TLR3 and 9, respectively. There was no obvious difference in the incidence of spontaneous diabetes between TLR3-deficient mice and TLR3 heterozygous mice. However, TLR9-deficient mice were markedly protected from the disease compared to TLR9 heterozygous mice. Our results suggest that different TLRs play a varying role in autoimmune diseases.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 0077-8923
Last Modified: 09 Oct 2017 13:14
URI: http://orca.cf.ac.uk/id/eprint/105284

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