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Hippocampal regulation of postsynaptic density Homer1 by associative learning

Clifton, Nicholas, Cameron, Darren, Trent, Simon, Sykes, Lucy Helen, Thomas, Kerrie Lorraine and Hall, Jeremy 2017. Hippocampal regulation of postsynaptic density Homer1 by associative learning. Neural Plasticity 2017 , 5959182. 10.1155/2017/5959182

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Abstract

Genes involved in synaptic plasticity, particularly genes encoding proteins in the postsynaptic density, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to the regulation of synaptic plasticity through the competing actions of their short and long isoforms. The expression of short Homer1 isoforms, Homer1a and Ania-3, is activity-induced and thought to be related to processes of learning and memory. However, the precise regulation of Homer1a and Ania-3 with different components of learning has not been investigated. Here, we used in situ hybridization to quantify short and long Homer1 expression in the hippocampus following consolidation, retrieval and extinction of associative fear memory, using contextual fear conditioning in rats. Homer1a and Ania-3, but not long Homer1, were regulated by contextual fear learning or novelty detection, although their precise patterns of expression in CA1, CA3 and dentate gyrus subregions were dependent on the isoform. The two isoforms are also regulated in CA1 by short and long novel context exposure. We also show for the first time that the two short Homer1 isoforms are regulated after the recall of contextual fear memory associated with reconsolidation and extinction, albeit with distinct temporal and spatial profiles. These findings support a role of activity-induced Homer1 isoforms in learning and memory processes in discrete hippocampal subregions and suggest that Homer1a and Ania-3 may play separable roles in synaptic plasticity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Hindawi Publishing
ISSN: 2090-5904
Date of First Compliant Deposit: 10 October 2017
Date of Acceptance: 10 October 2017
Last Modified: 25 Feb 2019 23:43
URI: http://orca.cf.ac.uk/id/eprint/105386

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