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The role of CD27 in anti-viral T-cell immunity

Grant, Emma J, Nüssing, Simone, Sant, Sneha, Clemens, E Bridie and Kedzierska, Katherine 2017. The role of CD27 in anti-viral T-cell immunity. Current Opinion in Virology 22 , pp. 77-88. 10.1016/j.coviro.2016.12.001

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Abstract

CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1879-6257
Last Modified: 12 Jul 2019 14:17
URI: https://orca.cardiff.ac.uk/id/eprint/106525

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