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Cancer stem cells as targets for immunotherapy

Codd, Amy S., Kanaseki, Takayuki, Torigo, Toshihiko and Tabi, Zsuzsanna 2018. Cancer stem cells as targets for immunotherapy. Immunology 153 (3) , pp. 304-314. 10.1111/imm.12866

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Abstract

Current cancer therapies target the bulk of the tumour, while a population of highly resistant tumour cells may be able to repopulate the tumour and metastasize to new sites. Cancer cells with such stem cell‐like characteristics can be identified based on their phenotypical and/or functional features which may open up ways for their targeted elimination. In this review we discuss potential off‐target effects of inhibiting cancer stem‐cell self‐renewal pathways on immune cells, and summarize some recent immunological studies specifically targeting cancer stem cells based on their unique antigen expressio

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley Blackwell
ISSN: 0019-2805
Funders: Tenovus Cancer Care
Date of First Compliant Deposit: 16 January 2018
Date of Acceptance: 2 November 2017
Last Modified: 18 Nov 2018 02:30
URI: http://orca.cf.ac.uk/id/eprint/106754

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