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Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: Virulent transmissible strains of genomovar III can replace Burkholderia multivorans

Mahenthiralingam, Eshwar, Vandamme, Peter, Campbell, Maureen E., Henry, Deborah A., Gravelle, Anna M., Wong, Lawrence T. K., Davidson, A. George F., Wilcox, Pearce G., Nakielna, Barbara and Speert, David P. 2001. Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: Virulent transmissible strains of genomovar III can replace Burkholderia multivorans. Clinical Infectious Diseases 33 (9) , pp. 1469-1475. 10.1086/322684

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Abstract

Infection with Burkholderia cepacia complex in patients with cystic fibrosis (CF) results in highly variable clinical outcomes. The purpose of this study was to determine if there are genomovar-specific disparities in transmission and disease severity. B. cepacia complex was recovered from 62 patients with CF on ?1 occasions (genomovar III, 46 patients; genomovar II [B. multivorans], 19 patients; genomovar IV [B. stabilis], 1 patient; genomovar V [B. vietnamiensis], 1 patient; and an unclassified B. cepacia complex strain, 1 patient). Patientto- patient spread was observed with B. cepacia genomovar III, but not with B. multivorans. Genomovar III strains replaced B. multivorans in 6 patients. Genomovar III strains were also associated with a poor clinical course and high mortality. Infection control practices should be designed with knowledge about B. cepacia complex genomovar status; patients infected with transmissible genomovar III strains should not be cohorted with patients infected with B. multivorans and other B. cepacia genomovars.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: “You may place your published article in a non-commercial data repository maintained by an institution of which you are a member, provided you meet all relevant conditions described in these Guidelines and in the editorial office’s communications with you. An institutional repository, as distinguished from your personal or departmental web site, is designed for the systematic storage, retrieval, and delivery of scholarly material. Your article may be made publicly available after the appropriate embargo period* [12 months or 3 years for Publications of the Astronomical Society of the Pacific] has been observed. You are responsible for informing the manager of the institutional repository of the embargo period that must be observed. See: http://www.jstor.org/page/publisher/ucpress/rights.html
ISSN: 1537-6591
Last Modified: 04 Jun 2017 01:37
URI: http://orca.cf.ac.uk/id/eprint/1069

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