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Psychiatric genomics: an update and an agenda

Sullivan, Patrick F., Agrawal, Arpana, Bulik, Cynthia M., Andreassen, Ole A., Børglum, Anders D., Breen, Gerome, Cichon, Sven, Edenberg, Howard J., Faraone, Stephen V., Gelernter, Joel, Mathews, Carol A., Nievergelt, Caroline M., Smoller, Jordan W. and O'Donovan, Michael Conlon 2017. Psychiatric genomics: an update and an agenda. American Journal of Psychiatry 175 (1) , pp. 15-27. 10.1176/appi.ajp.2017.17030283

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Abstract

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. This global effort is dedicated to rapid progress and open science, and in the past decade it has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders. The PGC has recently commenced a program of research designed to deliver “actionable” findings—genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) deliver new therapeutic targets. The central idea of the PGC is to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering a phase of accelerated genetic discovery for multiple psychiatric disorders. These findings are likely to elucidate the genetic portions of these truly complex traits, and this knowledge can then be mined for its relevance for improved therapeutics and its impact on psychiatric practice within a precision medicine framework.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: American Psychiatric Association
ISSN: 0002-953X
Date of First Compliant Deposit: 28 February 2018
Date of Acceptance: 15 May 2017
Last Modified: 05 Oct 2018 05:31
URI: http://orca.cf.ac.uk/id/eprint/106961

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