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Caenorhabditis elegans predation on Bacillus anthracis: Decontamination of spore contaminated soil with germinants and nematodes

Schelkle, Bettina, Choi, Young, Baillie, Leslie W., Richter, William, Buyuk, Fatih, Celik, Elif, Wendling, Morgan, Sahin, Mitat and Gallagher, Theresa 2018. Caenorhabditis elegans predation on Bacillus anthracis: Decontamination of spore contaminated soil with germinants and nematodes. Frontiers in Microbiology 8 , 2106. 10.3389/fmicb.2017.02601

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Abstract

Remediation of Bacillus anthracis-contaminated soil is challenging and approaches to reduce overall spore levels in environmentally contaminated soil or after intentional release of the infectious disease agent in a safe, low-cost manner are needed. B. anthracis spores are highly resistant to biocides, but once germinated they become susceptible to traditional biocides or potentially even natural predators such as nematodes in the soil environment. Here, we describe a two-step approach to reducing B. anthracis spore load in soil during laboratory trials, whereby germinants and Caenorhabditis elegans nematodes are applied concurrently. While the application of germinants reduced B. anthracis spore load by up to four logs depending on soil type, the addition of nematodes achieved a further log reduction in spore count. These laboratory based results suggest that the combined use of nematodes and germinants could represent a promising approach for the remediation of B. anthracis spore contaminated soil.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Additional Information: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
Publisher: Frontiers Media
ISSN: 1664-302X
Date of First Compliant Deposit: 8 January 2018
Date of Acceptance: 13 December 2017
Last Modified: 08 Sep 2020 14:45
URI: http://orca.cf.ac.uk/id/eprint/107971

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