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Changes in the retreatment radiation tolerance of the spinal cord with time after the initial treatment

Woolley, Thomas, Belmonte-Beitia, Juan, Calvo, Gabriel F., Hopewell, John W., Gaffney, Eamonn A. and Jones, Bleddyn 2018. Changes in the retreatment radiation tolerance of the spinal cord with time after the initial treatment. International Journal of Radiation Biology 94 , pp. 515-531. 10.1080/09553002.2018.1430911

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Abstract

Purpose: To estimate, from experimental data, the retreatment radiation ‘tolerances’ of the spinal cord at different times after initial treatment. Materials and methods: A model was developed to show the relationship between the biological effective doses (BED) for two separate courses of treatment with the BED of each course being expressed as a percentage of the designated ‘retreatment tolerance’ BED value, denoted {BED}_1 and {BED}_2. The primate data of Ang et al (2001) was used to determine the fitted parameters. However, based on rodent data, recovery was assumed to commence 70 days after the first course was complete, and with a non-linear relationship to the magnitude of the initial BED (BEDinit). Results: The model, taking into account the above processes, provides estimates of the retreatment tolerance dose after different times. Extrapolations from the experimental data can provide conservative estimates for the clinic, with a lower acceptable myelopathy incidence. Care must be taken to convert the predicted {BED}_2 value into a formal BED value and then a practical dose fractionation schedule. Conclusions: Used with caution, the proposed model allows estimations of retreatment doses with elapsed times ranging from 70 days up to three years after the initial course of treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Mathematics
Subjects: Q Science > QA Mathematics
Q Science > QA Mathematics > QA76 Computer software
Q Science > QH Natural history > QH301 Biology
R Medicine > RB Pathology
R Medicine > RD Surgery
Publisher: Informa Healthcare
ISSN: 0955-3002
Last Modified: 23 Aug 2018 15:45
URI: http://orca.cf.ac.uk/id/eprint/108250

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