Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Immunogenetic novelty confers a selective advantage in host-pathogen coevolution

Phillips, Karl P., Cable, Joanne, Mohammed, Ryan S., Herdegen-Radwan, Magdalena, Raubic, Jaroslaw, Przesmycka, Karolina J., van Oosterhout, Cock and Radwan, Jacek 2018. Immunogenetic novelty confers a selective advantage in host-pathogen coevolution. Proceedings of the National Academy of Sciences 115 (7) , pp. 1552-1557. 10.1073/pnas.1708597115

[img]
Preview
PDF - Accepted Post-Print Version
Download (255kB) | Preview

Abstract

The major histocompatibility complex (MHC) is crucial to the adaptive immune response of vertebrates and is among the most polymorphic gene families known. Its high diversity is usually attributed to selection imposed by fast-evolving pathogens. Pathogens are thought to evolve to escape recognition by common immune alleles, and, hence, novel MHC alleles, introduced through mutation, recombination or gene flow, are predicted to give hosts superior resistance. Although this theoretical prediction underpins host-pathogen ‘Red Queen’ coevolution, it has not been demonstrated in the context of natural MHC diversity. Here, we experimentally tested whether novel MHC variants (both alleles and functional ‘supertypes’) increased resistance of guppies (Poecilia reticulata) to a common ectoparasite (Gyrodactylus turnbulli). We used exposure-controlled infection trials with wild-sourced parasites, and Gyrodactylus-naïve host fish that were F2 descendants of crossed wild populations. Hosts carrying MHC variants (alleles or supertypes) that were new to a given parasite population experienced a 35-37% reduction in infection intensity, but the number of MHC variants carried by an individual, analogous to heterozygosity in single-locus systems, was not a significant predictor. Our results provide direct evidence of novel MHC advantage, confirming a fundamental mechanism underpinning the exceptional polymorphism of this gene family, and highlighting the role of immunogenetic novelty in host-pathogen coevolution

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: National Academy of Sciences
ISSN: 0027-8424
Date of First Compliant Deposit: 23 January 2018
Date of Acceptance: 18 December 2017
Last Modified: 09 Aug 2018 12:13
URI: http://orca.cf.ac.uk/id/eprint/108374

Citation Data

Cited 9 times in Google Scholar. View in Google Scholar

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics