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Association of combined patterns of tobacco and cannabis use in adolescence with psychotic experiences

Jones, Hannah J., Gage, Suzanne H., Heron, Jon, Hickman, Matthew, Lewis, Glyn, Munafò, Marcus R. and Zammit, Stanley 2018. Association of combined patterns of tobacco and cannabis use in adolescence with psychotic experiences. JAMA Psychiatry 10.1001/jamapsychiatry.2017.4271

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Importance There is concern about potentially causal effects of tobacco use on psychosis, but epidemiological studies have been less robust in attempts to minimize effects of confounding than studies of cannabis use have been. Objectives To examine the association of patterns of cigarette and cannabis use with preceding and subsequent psychotic experiences, and to compare effects of confounding across these patterns. Design, Setting, and Participants This cohort study used data from the Avon Longitudinal Study of Parents and Children, which initially consisted of 14 062 children. Data were collected periodically from September 6, 1990, with collection ongoing, and analyzed from August 8, 2016, through June 14, 2017. Cigarette and cannabis use data were summarized using longitudinal latent class analysis to identify longitudinal classes of substance use. Associations between classes and psychotic experiences at age 18 years were assessed. Exposures Depending on the analysis model, exposures were longitudinal classes of substance use or psychotic experiences at age 12 years. Main Outcomes and Measures Logistic regression was used to examine the associations between substance use longitudinal classes and subsequent onset of psychotic experiences.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics
Publisher: American Medical Association
ISSN: 2168-622X
Last Modified: 24 Jan 2018 14:31

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