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In Vivo models for inflammatory arthritis

Jones, Gareth, Hill, David, Sime, Katie and Williams, Anwen 2018. In Vivo models for inflammatory arthritis. In: Jenkins, B ed. Inflammation and Cancer. Methods in Molecular Biology, Vol. 1725. Methods in Molecular Biology, New York, NY: Humana Press, pp. 101-118. (10.1007/978-1-4939-7568-6_9)

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Abstract

In vivo mouse models of inflammatory arthritis are extensively used to investigate pathogenic mechanisms governing inflammation-driven joint damage. Two commonly utilized models include collagen-induced arthritis (CIA) and methylated bovine serum albumin (mBSA) antigen-induced arthritis (AIA). These offer unique advantages for modeling different aspects of human disease. CIA involves breach of immunological tolerance resulting in systemic autoantibody-driven arthritis, while AIA results in local resolving inflammatory flares and articular T cell-mediated damage. Despite limitations that apply to all animal models of human disease, CIA and AIA have been instrumental in identifying pathogenic mediators, immune cell subsets and stromal cell responses that determine disease onset, progression, and severity. Moreover, these models have enabled investigation of disease phases not easily studied in patients and have served as testing beds for novel biological therapies, including cytokine blockers and small molecule inhibitors of intracellular signaling that have revolutionized rheumatoid arthritis treatment.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Humana Press
ISBN: 978-1-4939-7567-9
Date of First Compliant Deposit: 2 February 2018
Date of Acceptance: 8 November 2017
Last Modified: 07 Jul 2019 01:54
URI: http://orca.cf.ac.uk/id/eprint/108562

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