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Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory

Scott, Hannah, Smith, Anna E., Barker, Gareth R., Uney, James B. and Warburton, E. Clea 2017. Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory. Neuroepigenetics 9 , pp. 1-9. 10.1016/j.nepig.2017.02.001

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Abstract

Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood. Here we investigated the roles of two epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition memory. Infusion of DNA methyltransferase inhibitors into PRh impaired performance in novel object recognition and object-in-place tasks while infusions into HPC or mPFC impaired object-in-place performance only. In contrast, inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition memory. These results support the emerging role of epigenetic processes in learning and memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 2214-7845
Date of Acceptance: 27 February 2017
Last Modified: 20 Feb 2018 11:10
URI: http://orca.cf.ac.uk/id/eprint/109247

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