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Automated operant assessments of Huntington's disease mouse model

Yhnell, Emma and Heuer, Andreas 2018. Automated operant assessments of Huntington's disease mouse model. Methods Molecular Biology, Springer Nature,

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Abstract

Huntington’s disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviourally tested and characterised. Operant behavioural testing offers an automated and objective method of behaviourally profiling motor, cognitive and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioural changes observed after any associated interventions or experimental therapeutics. We here present an overview on the most commonly used operant behavioural tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of Huntington’s disease.

Item Type: Book Section
Status: In Press
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Springer Nature
Date of First Compliant Deposit: 6 March 2018
Date of Acceptance: 23 March 2018
Last Modified: 06 Mar 2018 15:14
URI: http://orca.cf.ac.uk/id/eprint/109696

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