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Fat body cells are motile and actively migrate to wounds to drive repair and prevent infection

Franz, Anna, Wood, Will and Martin, Paul 2018. Fat body cells are motile and actively migrate to wounds to drive repair and prevent infection. Developmental Cell 44 (4) , 460-470.e3. 10.1016/j.devcel.2018.01.026

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Abstract

Adipocytes have many functions in various tissues beyond energy storage, including regulating metabolism, growth, and immunity. However, little is known about their role in wound healing. Here we use live imaging of fat body cells, the equivalent of vertebrate adipocytes in Drosophila, to investigate their potential behaviors and functions following skin wounding. We find that pupal fat body cells are not immotile, as previously presumed, but actively migrate to wounds using an unusual adhesion-independent, actomyosin-driven, peristaltic mode of motility. Once at the wound, fat body cells collaborate with hemocytes, Drosophila macrophages, to clear the wound of cell debris; they also tightly seal the epithelial wound gap and locally release antimicrobial peptides to fight wound infection. Thus, fat body cells are motile cells, enabling them to migrate to wounds to undertake several local functions needed to drive wound repair and prevent infections.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Elsevier (Cell Press)
ISSN: 1534-5807
Date of First Compliant Deposit: 14 March 2018
Date of Acceptance: 29 January 2018
Last Modified: 04 Jun 2020 10:45
URI: http://orca.cf.ac.uk/id/eprint/109876

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