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The neonatal window of opportunity-early priming for life

Renz, Harald, Adkins, Becky D., Bartfeld, Sina, Blumberg, Richard S., Farber, Donna L., Garssen, Johan, Ghazal, Peter, Hackam, David J., Marsland, Benjamin J., McCoy, Kathy D., Penders, John, Prinz, Immo, Verhasselt, Valerie, von Mutius, Erika, Weiser, Jeffrey N., Wesemann, Duane R. and Hornef, Mathias W. 2017. The neonatal window of opportunity-early priming for life. Journal of Allergy and Clinical Immunology 10.1016/j.jaci.2017.11.019

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Abstract

The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for lifelong host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome, and promote immune maturation. During the conference on “The neonatal window of opportunity – early priming for life,” postnatal microbiome and immune maturation, epidemiological evidence, and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures. From December 5 to 7, 2016, the Herrenhausen Conference “The neonatal window of opportunity – early priming for life” took place at Hannover, Germany, sponsored by the Volkswagen Foundation. The concept of the “neonatal window of opportunity,” that is, a critical nonredundant time frame in a newborn's life during which environmental factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life, was discussed.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0091-6749
Date of Acceptance: 15 November 2017
Last Modified: 21 May 2018 17:59
URI: http://orca.cf.ac.uk/id/eprint/109887

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