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Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force

Schwarze, J., Openshaw, P., Jha, A, Del Giacco, S.R., Firinu, D., Tsilochristou, O., Roberts, G., Selby, A., Akdis, C., Agache, I., Custovic, A., Heffler, E., Pinna, G., Khaitov, M., Nikonova, A., Papadopoulos, N., Akhlaq, A., Nurmatov, Ulugbek, Renz, H., Sheikh, A. and Skevaki, C. 2018. Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force. Allergy 73 (6) , pp. 1151-1181. 10.1111/all.13333

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Abstract

To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 0105-4538
Date of First Compliant Deposit: 15 March 2018
Date of Acceptance: 15 October 2017
Last Modified: 30 Jun 2019 20:14
URI: http://orca.cf.ac.uk/id/eprint/109898

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