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Back to the future: learning from cancer vaccine trials in Cardiff

Man, Stephen 2013. Back to the future: learning from cancer vaccine trials in Cardiff. Applied Immunohistochemistry and Molecular Morphology 21 (2) , pp. 110-115. 10.1097/PAI.0b013e3182811612

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Abstract

The early 1990s saw the first clinical testing of several therapeutic cancer vaccines. There was great optimism that these vaccines could be used as an alternative therapy for patients who had failed to respond to conventional cancer therapies. This article provides a personal perspective on the cancer vaccine field after being involved with a series of clinical trials in the United Kingdom (Cardiff) starting in the mid 1990s. It will also review the developments in technology and improved knowledge of the immune system that have informed the design of a new generation of cancer vaccine trials that will start in Cardiff in 2012.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Adoptive Transfer;Cancer Vaccines/immunology;Cancer Vaccines/therapeutic use*;Clinical Trials as Topic/trends;Female;Human papillomavirus 16/genetics;Human papillomavirus 16/immunology;Human papillomavirus 18/genetics;Human papillomavirus 18/immunology;Humans;Oncogene Proteins, Viral/genetics;Oncogene Proteins, Viral/immunology;Papillomavirus Infections/immunology;Papillomavirus Infections/pathology;Papillomavirus Infections/prevention & control*;T-Lymphocytes/immunology*;T-Lymphocytes/transplantation;United Kingdom;Uterine Cervical Neoplasms/immunology;Uterine Cervical Neoplasms/pathology;Uterine Cervical Neoplasms/prevention & control*;Vaccines, Synthetic
Publisher: Lippincott, Williams & Wilkins
ISSN: 1541-2016
Date of Acceptance: 3 December 2012
Last Modified: 19 Mar 2018 14:39
URI: http://orca.cf.ac.uk/id/eprint/109944

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