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Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study

Mohan, Divya, Forman, Julia R., Allinder, Matthew, McEniery, Carmel M., Bolton, Charlotte Emma, Cockcroft, John R., MacNee, William, Fuld, Jonathan, Marchong, Mellone, Gale, Nichola Sian, Fisk, Marie, Nagarajan, Sridevi, Cheriyan, Joseph, Lomas, David A., Calverley, Peter M.A., Miller, Bruce E., Tal-Singer, Ruth, Wilkinson, Ian B. and Polkey, Michael I. 2018. Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. Thorax 73 (12) , pp. 1182-1185. 10.1136/thoraxjnl-2018-211556

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Abstract

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator—fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II–IV COPD. The cardiovascular and muscular manifestations exist independently (P=0.22, χ2). Fibrinogen was not associated with aPWV or QMVC (P=0.628 and P=0.621, respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Healthcare Sciences
Additional Information: Released with a Creative Commons Attribution Non-Commercial License (CC BY-NC)
Publisher: BMJ Publishing Group
ISSN: 0040-6376
Date of First Compliant Deposit: 16 March 2018
Date of Acceptance: 12 March 2018
Last Modified: 25 Nov 2020 09:15
URI: http://orca.cf.ac.uk/id/eprint/109950

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