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Interferon control of the sterol metabolic network: bidirectional molecular circuitry-mediating host protection

Robertson, Kevin A. and Ghazal, Peter 2016. Interferon control of the sterol metabolic network: bidirectional molecular circuitry-mediating host protection. Frontiers in Immunology 7 10.3389/fimmu.2016.00634

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Abstract

The sterol metabolic network is emerging center stage in inflammation and immunity. Historically, observational clinical studies show that hypocholesterolemia is a common side effect of interferon (IFN) treatment. More recently, comprehensive systems-wide investigations of the macrophage IFN response reveal a direct molecular link between cholesterol metabolism and infection. Upon infection, flux through the sterol metabolic network is acutely moderated by the IFN response at multiple regulatory levels. The precise mechanisms by which IFN regulates the mevalonate-sterol pathway—the spine of the network—are beginning to be unraveled. In this review, we discuss our current understanding of the multifactorial mechanisms by which IFN regulates the sterol pathway. We also consider bidirectional communications resulting in sterol metabolism regulation of immunity. Finally, we deliberate on how this fundamental interaction functions as an integral element of host protective responses to infection and harmful inflammation.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Uncontrolled Keywords: cholesterol, sterol, interferon, metabolism, miRNA, oxysterol, 25-hydroxycholesterol, miR-342-5p
Publisher: Frontiers Research Foundation
ISSN: 1664-3224
Date of First Compliant Deposit: 29 August 2018
Date of Acceptance: 12 December 2016
Last Modified: 29 Aug 2018 14:23
URI: http://orca.cf.ac.uk/id/eprint/110062

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