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Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection

Kotzamanis, Konstantinos, Angulo, Ana and Ghazal, Peter 2015. Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection. Medical Microbiology and Immunology 204 (3) , pp. 395-407. 10.1007/s00430-015-0402-5

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Abstract

Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both immune and metabolic pathways is altered yet these changes are often investigated in isolation. Here, we summarise our current understanding of these processes in the context of a clinically relevant pathogen, cytomegalovirus. We synthesise from the literature an integrative view of a coupled immune–metabolic infection process, centred on sugar and lipid metabolism. We put forward the notion that understanding immune control of key metabolic enzymatic steps in infection will promote the future development of novel therapeutic modalities based on metabolic modifiers that either enhance protection or inhibit infection.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Uncontrolled Keywords: Infection; Glycolysis; CMV; Fatty acid synthesis; Metabolism; Inflammation
Publisher: Springer
ISSN: 0300-8584
Last Modified: 21 Mar 2018 08:19
URI: http://orca.cf.ac.uk/id/eprint/110063

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