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Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products

Baptista, Rafael, Bhowmick, Sumana, Nash, Robert J., Baillie, Les and Mur, Luis AJ 2018. Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products. Future Medicinal Chemistry 10 (7) , pp. 811-822. 10.4155/fmc-2017-0273

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Abstract

Tuberculosis is a major global health hazard. The search for new antimycobacterials has focused on such as screening combinational chemistry libraries or designing chemicals to target predefined pockets of essential bacterial proteins. The relative ineffectiveness of these has led to a reappraisal of natural products for new antimycobacterial drug leads. However, progress has been limited, we suggest through a failure in many cases to define the drug target and optimize the hits using this information. We highlight methods of target discovery needed to develop a drug into a candidate for clinical trials. We incorporate these into suggested analysis pipelines which could inform the research strategies to accelerate the development of new drug leads from natural products.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: Future Science
ISSN: 1756-8919
Date of First Compliant Deposit: 3 April 2018
Date of Acceptance: 23 March 2018
Last Modified: 26 Jul 2018 14:47
URI: http://orca.cf.ac.uk/id/eprint/110455

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