Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Vision and locomotion shape the interactions between neuron types in mouse visual cortex

Dipoppa, Mario, Ranson, Adam, Krumin, Michael, Pachitariu, Marius, Carandini, Matteo and Harris, Kenneth D. 2018. Vision and locomotion shape the interactions between neuron types in mouse visual cortex. Neuron 98 (3) , pp. 602-615. 10.1016/j.neuron.2018.03.037

[img]
Preview
PDF - Accepted Post-Print Version
Available under License Creative Commons Attribution.

Download (6MB) | Preview

Abstract

Cortical computation arises from the interaction of multiple neuronal types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such interactions, we imaged these four types of cells in mouse primary visual cortex (V1). Our recordings in darkness were consistent with a ‘‘disinhibitory’’ model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli. A recurrent network model successfully predicted each cell type’s activity from the measured activity of other types. Capturing the effects of locomotion, however, required allowing it to increase feedforward synaptic weights and modulate recurrent weights. This network model summarizes interneuron interactions and suggests that locomotion may alter cortical computation by changing effective synaptic connectivity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
Publisher: Elsevier (Cell Press)
ISSN: 0896-6273
Date of First Compliant Deposit: 24 April 2018
Date of Acceptance: 21 March 2018
Last Modified: 27 Jul 2018 20:45
URI: http://orca.cf.ac.uk/id/eprint/110902

Citation Data

Cited 21 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics