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Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

Newland, Benjamin, Taplan, C., Pette, D., Friedrichs, J., Steinhart, M., Wang, W., Voit, B., Seib, F. P. and Werner, C. 2018. Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery. Nanoscale 10 (18) , pp. 8413-8421. 10.1039/C8NR00603B

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Abstract

Nanotubes are emerging as promising materials for healthcare applications but the selection of clinically relevant starting materials for their synthesis remains largely unexplored. Here we present, for the first time, the synthesis of poly(ethylene glycol) (PEG) based nanotubes via the photopolymerization of poly(ethylene glycol) diacrylate and other diacrylate derivatives within the pores of anodized aluminum oxide templates. Template-assisted synthesis allowed the manufacture of a diverse set of polymeric nanotubes with tunable physical characteristics including diameter (∼200–400 nm) and stiffness (405–902 kPa). PEG nanotubes were subjected to cytotoxicty assessment in cell lines and primary stem cells and showed excellent cytocompatability (IC50 > 120 μg ml−1). Nanotubes were readily drug loaded but released the majority of the drug over 5 days. Direct administration of drug loaded nanotubes to human orthotopic breast tumors substantially reduced tumor growth and metastasis and outperformed i.v. administration at the equivalent dose. Overall, this nanotube templating platform is emerging as a facile route for the manufacture of poly(ethylene glycol) nanotubes.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Pharmacy
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Royal Society of Chemistry
ISSN: 2040-3364
Date of First Compliant Deposit: 3 May 2018
Date of Acceptance: 27 March 2018
Last Modified: 02 Aug 2018 14:30
URI: http://orca.cf.ac.uk/id/eprint/111177

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